Significats de chromosomal looping en anglès

We found that paxillin interacts with cohesin and the mediator complex, which have been shown to mediate long-range chromosomal looping.

Enhancers, which function by bringing activating complexes to promoters through chromosomal looping, are also modulated by a combination of DNA methylation and histone modifications.

Our findings point to a functional link between schizophrenia-associated noncoding SNPs and 3D genome architecture associated with chromosomal loopings and transcriptional regulation in the brain.