Significats de clinically actionable en anglès

Some of these variants may be clinically actionable or may warrant genetic counseling.

Rate-of-change arrows on existing devices obscure clinically actionable glycemic trend information from CGM users.

Conclusions: We found potentially clinically actionable alterations in approximately 21% of patients with osteosarcoma.

Patients with clinically actionable inherited mutations whose genetic test results would not have been predicted by published decision rules were identified.

The overall detection rate of clinically actionable alterations, defined by modified OncoKB criteria, for all sequenced samples was 51%.

Thus, a clinically actionable method for the collection of synovial tissue, which can be analyzed using high-throughput strategies, must become a reality.

This targeted next-generation sequencing approach allows for detection of common and also rare mutations that are clinically actionable in multiple patients simultaneously.

Main outcomes and measures: Proportion of clinically actionable germline mutations detected by universal tumor-normal sequencing that would not have been detected by guideline-directed testing.

Importance: Guidelines for cancer genetic testing based on family history may miss clinically actionable genetic changes with established implications for cancer screening or prevention.

Conclusions: We found a remarkably high number of clinically actionable mutations in 51% of the patients, and 12% with significant germline mutations.

Potentially actionable genetic events were categorized according to the OncoKB precision oncology knowledge base, of which levels 1 to 3 were considered clinically actionable.