Significats de conserve histidine en anglès

Directed mutagenesis of the protein reveals two highly conserved histidine residues required for function.

We identified a conserved histidine in GAPDH that is needed for its robust heme binding both in vitro and in mammalian cells.

The dimetal centre is coordinated by a unique spacial arrangement of nine conserved histidine residues that implies a potentially novel mechanism for oxygen activation.