Significats de conserved epitopes en anglès

These data underline the need for a CTL vaccine against multiple conserved epitopes.

Additional desirable elements are multispecificity and a focus on conserved epitopes.

Maintained immune responses to conserved epitopes were associated with no or limited sequence evolution within the targeted epitope.

This binding to CD4 reveals cryptic and highly conserved epitopes, the molecular nature of which is still not fully understood.

Human broadly neutralizing antibodies directed against highly conserved epitopes in the stem region of influenza virus HA have been recently characterized.

Here, we report the identification and characterization of linear, HA subtype-specific as well as inter subtype- conserved epitopes along the HA proteins.

However, it remains unknown what the baseline levels are of antibodies and memory B cells that are directed against these conserved epitopes.

The use of multiple conserved epitopes arranged in an artificial gene (or EpiGene) is a potential means to achieve these goals.

Novel influenza virus vaccines that redirect the immune response toward conserved epitopes of the HA stalk domain should afford broad and durable protection.

These antibodies predominantly recognized conserved epitopes involving both of the constituent epidermal growth factor-like domains of MSP-1(19).