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1Selection criteria: Only randomised control trials of patients with COPD were included.
2These control trials are included in those given in the foregoing paragraph.
3Setting: Critical care randomised control trials in severe sepsis and septic shock.
4Seventeen were randomized control trials and 8 were nonrandomized control trials.
5Effectiveness assumptions for each scenario were based on systematic reviews and randomised control trials.
6Eight studies were randomized control trials (RCTs) and enrolled 321 participants.
7Main results: Twenty-nine randomized control trials were included.
8Further prospective randomized control trials are warranted to clarify the utility of NHB therapy in LVAD patients.
9Methods: Analysis of patient-level data from 3 large surgical randomized controlled trials.
10Further studies, particularly randomized controlled trials, are needed to confirm these benefits.
11Results: The majority of the eleven eligible studies were randomized controlled trials.
12Results: We identified eight randomized controlled trials that satisfied all inclusion criteria.
13Further investigation with randomized controlled trials should be considered in future studies.
14These randomized controlled trials are considered the gold standard of medical research.
15Placebo- controlled trials are used widely in the development of new pharmacological treatments.
16Methods: This was a follow-up study of two large randomized controlled trials.