Significats de deep gm en anglès

Conclusions: Longitudinal deep GM atrophy measures should be interpreted with caution.

However, quantitative data on the reproducibility of deep GM structure volumetry are not yet available.

Conclusions: Hippocampal and deep GM nuclei atrophy are key factors associated with cognitive impairment in MS.

Furthermore, deep GM atrophy measurement techniques require substantially improved reproducibility, specifically when aiming for personalized medicine.

Additional associations between cortical GM atrophy and deep GM iron accumulation appear to exist in a region specific manner.

Conclusion: Iron accumulation in deep GM of MS patients is most strongly and independently associated with duration and severity of the disease.

Hippocampal and deep GM nuclei atrophy were the best predictors of cognitive impairment, while WM atrophy was the best predictor of disability.

Focal WM and cortical lesions were identified, and volumetric measures from WM, cortical GM, the hippocampus, and deep GM nuclei were obtained.

Reduced cortical volume was not associated with iron accumulation in the deep GM with the exception of the substantia nigra and the red nucleus.

R2*in deep GM was corrected for age and was related to disease duration, disability, T2 lesion load and brain volume.