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Results: Using transiently immunocompromised mice, we established a model of mild denguedisease with measurable viremia.
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Typically, patients presenting with acute denguedisease are viremic but may not have yet developed detectable titers of antibody.
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Background: Early identification of patients at risk of severe denguedisease (DD) is critical to guide its management.
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Conclusions: Dengvaxia has the potential to reduce the burden of denguedisease in areas of moderate to high dengue endemicity.
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The recognition of these known warning signs associated to severe denguedisease underlines the usefulness of the WHO 2009 classification.
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These results suggest that exogenously introduced siRNA combined with the endogenous RNA interference processing machinery has the capacity to prevent severe denguedisease.
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The observation that prior ZIKV infection can modulate denguedisease severity like a DENV serotype poses challenges to development of dengue and Zika vaccines.
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Denguedisease is currently a major health problem in Indonesia and affects all provinces in the country, including Semarang Municipality, Central Java province.