Methods and findings: A deterministicmodel of HIV transmission incorporating ART and stratifying infection progression into stages was constructed.
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Whereas the deterministicmodel cannot fully capture the observed behavior, our stochastic model correctly predicts the experimental dynamics without any fit parameters.
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A deterministicmodel incorporating selection coefficients measured during the same interval indicates that the transition was toward a state of recombination-selection equilibrium.
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However, for deterministicmodels, there is no confidence band that can be constructed.
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This approach extends the utility of nonparametric regression for model assessment to deterministicmodels.
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Chaotic rhythms in deterministicmodels can arise as a consequence of changes in model parameters.
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Food exposure is assessed through deterministicmodels.
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More often than not, analyses of virus evolution have considered that virus populations are so large that evolution can be explained by purely deterministicmodels.