Reduction of iron load, achieved by regular desferrioxamine infusion, resulted in normalisation of the urinary enzyme levels.
2
In the presence of desferrioxamine, adriamycin semiquinone does not disappear in the presence of hydrogen peroxide at a detectable rate.
3
No significant changes in the degree of IRI or AR were observed in the groups treated with desferrioxamine or melatonin.
4
In our study, treatment with the antioxidants melatonin or desferrioxamine before reperfusion had no effects on IRI damage or on AR frequency or severity.
1
Both NO inhibition and iron scavenging, using deferoxamine administration, reduced hydroxyl radical levels and neuronal cell death.
2
Likewise, depletion of iron by deferoxamine during induction of HO-1 by cobalt-protoporphyrin IX did not restore HCV replication.
3
DFE was 10 times more potent and more rapid in onset of effect than the clinically used iron chelator deferoxamine.
4
This increase was not significantly altered by SOD or deferoxamine, nor was it different from the mortality observed in air-exposed cells.
5
In patients previously exposed to aluminum, a deferoxamine test should be performed and a deferoxamine treatment started if the test is positive.
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However, early initiation of chelation has also been associated with DFO toxicity.
2
Herein, we clarify the effect and mechanism of action of DFO on angiogenesis.
3
The DFO must be selected from the ranks of SAA pilots.
4
None of the patients who attained final height had signs of DFO bone toxicity.
5
UUO-induced expression of inflammatory cytokines and extracellular matrix proteins was abrogated by DFO treatment.
6
Increased renal iron content was observed in UUO mice, which was reduced by DFO treatment.
7
Endothelial cell proliferation increased and oxidative stress and apoptosis decreased in ischemic muscles of DFO-treated mice.
8
The density of capillaries and arterioles in ischemic muscle was higher in DFO-treated mice compared to vehicle-treated mice.
9
Conclusion: These findings indicate that DFO promotes revascularization via the activation of vascular endothelial cell function by an Akt-eNOS-dependent mechanism.
10
These results suggest that iron reduction by DFO prevents renal tubulointerstitial fibrosis by regulating TGF-β-Smad signaling, oxidative stress, and inflammatory responses.
11
In an in vivo study, DFO promoted blood flow recovery in response to the hindlimb ischemia in mice with unilateral hindlimb surgery.
12
Dendrite branch number and length were reduced in 6 μm ELT-treated neurons, resulting in blunted dendritic arbor complexity that was similar to DFO-treated neurons.
13
The department gave Imperial a new permit on Friday to disturb fish habitat at the proposed northern Alberta mining site, DFO spokesman Phil Jenkins said.