Significats de distal enhancer en anglès

These findings elucidate the role of intra-TAD cohesin-and-CTCF binding in nuclear organization associated with widespread insulation of distal enhancer activity.

The hormonal response is mediated by a distal enhancer located 6.3 kb upstream of the transcription-start site.

Iterative chemical screening identified a combination of five kinase inhibitors that induces and maintains OCT4 distal enhancer activity when applied directly to conventional human ESCs.

A distal enhancer region drives expression in the deutocerebral brain anlage and a proximal enhancer region drives expression in the VNC and tritocerebral brain anlage.

Maximal stimulation of transcription by HNF-4 in Caco-2 cells required the presence of both the intestinal specific promoter, the NHRRE, and distal enhancer elements.

Outside of promoter regions, distal enhancers play a major role in the cell type-specific regulation of gene expression.

Because promoter- distal enhancers are key to cell fate decisions, we analyzed enhancer landscapes during mononuclear phagocyte development in vivo.

Distal enhancers characterized by the H3K4me(1) mark play critical roles in developmental and transcriptional programs.

Distal enhancers have emerged as key regulatory elements that acquire histone modifications in a cell- and species-specific manner, thus enforcing specific gene expression programs.