Significats de dormant tumors en anglès

We hypothesized that dormant tumors undergo a stable genetic reprogramming during their switch to the fast-growing phenotype.

Lack of experimental models and limited clinical accessibility constitute major obstacles to the molecular characterization of dormant tumors.

The switch of dormant tumors was associated with down-regulation of angiogenesis inhibitor thrombospondin and decreased sensitivity of angiogenic tumors to angiostatin.

Finally, these models may prove useful in the design and testing of therapies directed toward eradicating dormant tumors and preventing tumor recurrence.

Dormant tumors represent an early stage in tumor development and may therefore be a potential target for nontoxic, antiangiogenic therapy that could prevent tumor recurrence.