Incubation of drugcraving is a phenomenon that consists of time-dependent increases in cue-induced drugcraving during withdrawal.
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High rates of relapse after prolonged abstinence are often triggered by exposure to drug -associated cues that induce drugcraving.
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Previous studies have demonstrated that drug -seeking in rats progressively increases over time during withdrawal (incubation of drugcraving).
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Data suggest further exploration of guanfacine is warranted in terms of its potential for reducing stress-induced and cue-induced drugcraving and arousal.
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Findings suggest that progesterone's effects on drugcraving and arousal are moderated by both the type of environmental cue exposure and gender.
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These findings highlight sex-specific effects of guanfacine on drugcraving, anxiety, and negative mood with significant effects in women and not men.
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However, its effects on provoked drugcraving, stress arousal and cognitive performance has not been systematically investigated in cocaine dependent men and women.
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Relapse is often associated with stress exposure, which can provoke a subjective state of drugcraving that can also be demonstrated under controlled laboratory conditions.
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This review covers the neurobiology of drugcraving and relapse risk with a primary focus on cocaine addiction and a secondary emphasis on alcohol addiction.
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We identified 19 human studies using repetitive TMS (rTMS) to manipulate drugcraving or use, which exposed a total of 316 adults to active rTMS.
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The VTA is swarming with dopamine, a neurotransmitter associated with pleasure as well as drugcravings.
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In the study, the Beijing scientists tested a technique called "memory retrieval-extinction" to prevent drugcravings in heroin users.