Significats de endochondral ossification en anglès

Developing cartilage serves as a template for long-bone development during endochondral ossification.

The degradation of proteoglycans has been considered an essential step in the process of endochondral ossification.

Bone formation by endochondral ossification is considered a key pathophysiological process in the formation of osteophytes.

Histological observations and gene expression analysis showed stronger endochondral ossification elicited by strontium compared to rhBMP2.

During endochondral ossification, the cartilage is surrounded by a layer of cells that constitute the perichondrium.

These cartilage cells progressively differentiate and the tissue undergoes endochondral ossification, recapitulating the development of endochondral bone.

Recently, gene deletion revealed a predominant role of NPR-B in endochondral ossification and development of female reproductive organs.

TAP63a may promote endochondral ossification through interaction with genes relevant to matrix mineralization and chondrocyte maturation or apoptosis.

Chondrocytes of the growth plate undergo apoptosis during the process of endochondral ossification, as well as during the progression of osteoarthritis.

Mutant mice had decreased postnatal viability and growth, with a defect in endochondral ossification at epiphyseal plates similar to human hypochondroplasia.

During endochondral ossification, apoptosis of chondrocytes occurs concurrently with new bone formation and the resorption and replacement of mineralized cartilage with woven bone.

Although the coupling of cartilage and bone development with angiogenesis is an important regulatory step for endochondral ossification, the molecular mechanisms are poorly understood.

Introduction: During endochondral ossification, both the production of a cartilage template and the subsequent vascularisation of that template are essential precursors to bone tissue formation.

Herein, we describe a developmentally inspired approach to bone tissue engineering, which focuses on leveraging biomaterials as platforms for recapitulating the process of endochondral ossification.

During endochondral ossification, a small amount of metachromatic staining cartilage appeared at the fracture site, but there was no provisional calcification zone in the cartilage.