One patient who underwent LT is waiting for ENU due to post-cryotherapy complication.
2
Here we review progress in ENU mutagenesis screening, with an emphasis on creating mouse models for human disorders.
3
Our results demonstrate that the expression of differentiation antigens in ENU-induced experimental neurinomas parallels the results reported for human neurinomas.
4
ENU is a toxin and carcinogen as well as a mutagen, and strains differ in their susceptibility to its effects.
5
We report on a battery of behavioral screening tests that successfully identified several neurobehavioral mutants among a large-scale ENU-mutagenized mouse population.
6
Therefore, it is necessary to determine an appropriate mutagenic, non-toxic dose of ENU for strains that are to be used in experiments.
7
Transient suppression in zebrafish and analysis of an ENU mouse mutant confirmed in both model organisms that ARMC4 is critical for left-right patterning.
8
Our results revealed a more precise picture of the cellular differentiation in ENU-induced rat gliomas and in two widely used glioma cell lines.
9
Large numbers of ENU-mutagenized mice were screened for abnormalities in central nervous system function based on abnormal performance in a series of behavior tasks.
10
We identified ENU-induced point mutations in Sfrp5 and Sfrp2 that are predicted to severely disrupt the function of these genes.
11
Consequently, by treating patients according to our strategy, we were able to salvage 6 out of 10 eyes without ENU or EBRT.