All the flavone derivatives were highly selective for hMRP1-expressing cell lines.
2
The Ginkgo leaf flavone markedly inhibited the growth of human liver carcinoma cell line HepG2.
3
Some rigid analogues of flavone-8-acetic acid are described.
4
The most active compound resulted the one bearing a fluorine atom in position 7 of the flavone nucleus.
5
We report that several flavone derivatives and other polyphenols present in vegetables and plants inhibit ion and urea conduction and cell vacuolation by VacA.
6
When the crude leaves used the cellulase enzyme pretreatment before extraction process, the extraction yield of total flavone was up to 2.01%.
7
Background: Previously, the antitumour activity of some flavone-8-acetic acid (FAA) derivatives substituted with an acid function in position 2 of the benzene ring was evaluated.
8
In general, the 3-substituted flavones were the most potent compounds in this assay.
9
This study illuminates new properties of the flavones and provide additional insights into the ligand binding properties of L.donovani topoisomerase I.
10
Taken together, our data suggest that the interacting amino acid residues of topoisomerase I may be partially overlapping or different for flavones and CPT.
11
According to the correlation of primary the structure and activity, 8-methoxy substituent in these flavones may be a major factor of the antitumor activity.