We hypothesized that PKP2 may regulate focaladhesion dynamics and cell migration.
1
Nonetheless, focalcontact proteins are central to mechanisms that regulate skin cell motility.
2
These results implicate the peptide segment nearest to the transmembrane region in focalcontact localization.
3
Interaction between individual FNIII domains and beta1 integrins mediates focal adhesion kinase phosphorylation and subsequent stress fiber and focalcontact formation.
4
Remarkably, both focalcontact and hemidesmosomal proteins appear involved in determining the speed and directional migration of epidermal cells by modulating several signal transduction pathways.
5
PKC delta EC contained significantly greater numbers of focalcontacts per cell.
Ús de focal adhesions en anglès
1
Background: FAK localization to focaladhesions is essential for its activation and function.
2
Assembly and modulation of focaladhesions during dynamic adhesive processes are poorly understood.
3
Vinculin was identified as a component of focaladhesions and adherens junctions nearly 40 years ago.
4
Stress fibers and focaladhesions are complex protein arrays that produce, transmit and sense mechanical tension.
5
This results in a net increase in active Rho, and increased stress fibers and focaladhesions.
6
In cultured cells, the matrix receptors are concentrated in sites of cell attachment called focaladhesions.
7
Recent experimental evidence points to the importance of focaladhesions in the regulation of microvascular barrier function.
8
Stress fibers and focaladhesions reformed if cells were allowed to recover for 18 h after injection.
9
By 2 h after injection only a few small focaladhesions persisted, yet the cells remained spread.
10
Down-regulation of RECK by small interfering RNA showed reduced spreading and smaller focaladhesions in the chondrocytes.
11
We carried out experiments with fibroblasts varying in their ability to form actin stress fibers and focaladhesions.
12
These experiments suggest that talin has at least two sites that contribute to its localization in focaladhesions.
13
In addition, betaPIX facilitated the targeting of activated Rac1 to focaladhesions and the efficiency of cell spreading.
14
This is consistent with the codistribution of syndecan-4 with the alpha isoform of protein kinase C in focaladhesions.
15
The short-term (30 minutes) disassembly of focaladhesions is reflected in decreased adhesiveness of EGF-treated cells to substratum.
16
The number and size of focaladhesions as well as their intensity were largely unaffected by genetic removal of Rac1.