Significats de follicular helper en anglès

IL-27 supports GCs by promoting survival and function of T follicular helper cells.

Such DC targeting is also effective at enhancing humoral immunity, via the generation of T follicular helper cells.

Notably, bortezomib treatment induced germinal center B cell and follicular helper T cell expansion in the lymph nodes.

The recently described T follicular helper (Tfh) cell is required for the production of high affinity antibody.

Blimp-1 expression in T cells extinguishes the fate of T follicular helper cells, drives terminal differentiation, and limits autoimmunity.

A subset of human follicular helper T cells (TFH) cells expresses CD57 for which no distinct function has been identified.

The generation of protective humoral immunity after vaccination relies on the productive interaction between antigen-specific B cells and T follicular helper (Tfh) cells.

GC hyperplasia was also evidenced by an increase in numbers of circulating follicular helper T cells, which correlated with decreased regulatory T-cell frequencies and function.

Using this, we uncover that immune checkpoint therapy induces T follicular helper cell activation of B cells to facilitate the anti-tumor response in these models.

Tumor cells were positive for conventional T-cell antigens as well as for the follicular helper T-cell marker, PD-1, and CXCL13.