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1
We sought to identify factors required for epithelial repair followingNE exposure.
2
These results suggest ErbB2 is a critical factor for epithelial recovery followingNE exposure.
3
Immediately followingNE treatment, by flow cytometry analysis, we found a decrease in ErbB2 surface expression.
4
FollowingNE treatment, we found a marked and sustained decrease in epithelial proliferation as detected by Ki67 immunostaining.
5
We hypothesized that ErbB2 receptor tyrosine kinase, a regulator of cancer cell proliferation, was required for epithelial DNA synthesis followingNE exposure.