Significats de free hemoglobin en anglès

Acetaminophen may exert a protective effect by reducing cell- free hemoglobin-induced oxidative injury.

It also ruptures red blood cells, spilling free hemoglobin into bodily organs, where it's toxic.

Background & aims: Haptoglobin is an acute phase protein responsible for the recovery of free hemoglobin from plasma.

Adding antioxidant activities to hemoglobin-based oxygen carriers (HBOCs) represents a means of reducing cell- free hemoglobin-mediated oxidative cascades.

Up-regulation of the ferroportin transcript, but not of the protein, also occurs in haptoglobin-null spleen macrophages, which accumulate free hemoglobin-derived iron.

We have previously reported that circulating cell- free hemoglobin (CFH) is elevated during sepsis, and higher levels predict worse outcomes.

Conclusions: In critically ill patients with sepsis, elevated concentrations of circulating cell- free hemoglobin are independently associated with an increased risk of death.

In a subgroup, LDH levels closely correlated with plasma cell- free hemoglobin, accelerated NO consumption by plasma, and impaired vasodilatory responses to an NO donor.

Administration of hemoglobin-based oxygen carriers (HBOCs) frequently results in vasoconstriction that is primarily attributed to the scavenging of endothelium-derived nitric oxide (NO) by cell- free hemoglobin.