Significats de fulminant type en anglès

Results: Two iPSC clones were established from each of three patients with fulminant type 1 diabetes.

In this study, a comprehensive approach was applied to understand the pathogenesis of fulminant type 1 diabetes.

Conclusions: We generated iPSCs from patients with fulminant type 1 diabetes and differentiated them into insulin-producing cells.

This in vitro disease model can be used to elucidate the disease mechanisms of fulminant type 1 diabetes.

Materials and methods: iPSCs were generated from fibroblasts of patients with fulminant type 1 diabetes by inducing six reprogramming factors.

The differentiation of insulin-producing cells from fulminant type 1 diabetes iPSC was confirmed by immunofluorescence analysis and KCl-induced C-peptide secretion.

Emergence of anti-HBs in the presence of HBsAg did not always correspond to clearance of HBV in fulminant type B cases.

We conclude the presence of reduced NK activating receptor gene expression and low proportion of NK cells in fulminant type 1 diabetes.

Altered expression levels of several apoptosis-related genes were observed in INS-positive cells derived from the fulminant type 1 diabetes iPSCs by ribonucleic acid sequencing.

Ribonucleic acid sequencing was carried out to compare gene expressions in INS-positive cells derived from fulminant type 1 diabetes iPSC and control human iPSC lines.

Results: In fulminant type 1 diabetes, beta and alpha cell areas were decreased significantly, compared with autoimmune type 1 diabetes and control subjects.

Fulminant type 1 diabetes is an independent subtype of type 1 diabetes characterized by extremely rapid onset and absence of islet-related autoantibodies.