Significats de gastric organoids en anglès

We show that metabolites emanating from human gastric organoids rapidly attract H. pylori.

We then performed microarray analysis using three normal gastric organoids and three pairs of 5-FU-resistant and parental GCOs.

H. pylori infection of gastric organoids induced Shh expression; a response that was blocked by inhibiting NFkB signaling and correlated with IkB degradation.

Gastric organoids grow from isolated epithelial stem cells and develop into three dimensional structures that can be used to study host physiology.

Conclusion: Gastric organoids allow for the study of the interaction between H. pylori and the differentiated gastric epithelium independent of the host immune response.