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This reconstruction allowed us to identify candidate regulatory genecircuit elements underlying T cell fate decision making.
2
Using a synthetic genecircuit, we show that a transcriptional activator driven by yeast cell-cycle promoters propagates transcriptional oscillations with substantial damping.
3
Regulatory genecircuits enable stem and progenitor cells to detect and process developmental signals and make irreversible fate commitment decisions.
4
Accurately predicting noise propagation in gene networks is crucial for understanding signal fidelity in natural networks and designing noise-tolerant genecircuits.
5
The ability to create designer aTFs will enable applications including dynamic control of cell metabolism, cell biology and synthetic genecircuits.