Chemical inhibition or geneticknockdown of HO-1 potentiated hemin-triggered ROS generation and oxidative DNA damage preferentially in HCEC.
2
A geneticknockdown of ADK prevented SE in a mouse model, whereas transgenic overexpression of the enzyme aggravated the SE.
3
Pharmacological inhibition and geneticknockdown of Nox2 activity prevented SMase induced ROS production and provided protection against decreased force production in the diaphragm.
4
Further, geneticknockdown and antibody-mediated neutralization of uPA have been shown to be protective against induction or progression of arthritis in animal models.
5
Importantly, both MS-275 and geneticknockdown of Hdac3 alone were sufficient to restore glucose-stimulated insulin secretion in the presence of cytokines.
6
Geneticknockdown of PERK activity also reduces sleep in Drosophila, whereas PERK overexpression induces sleep.
7
Geneticknockdown of IRAK1 in primary AML samples and xenograft model showed a significant reduction in leukemia burden.
8
Geneticknockdown or pharmacological inhibition of SLO-1 in aged, but not young, worms can slow motor aging and prolong longevity.