We did not see relevant changes in granulocyte function in vitro after cA2 infusion.

To forestall a subsequent organ dysfunction, a short-term posttraumatic down-regulation of granulocyte function has been advocated.

A variety of immune deficits has been described in such patients, including a decreased primary antibody response and defects in complement and granulocyte function.

Granulocyte function in the spinal cord injured has not been evaluated.

Conclusion: These findings suggest that infusion of NAC in high doses affects granulocyte functions in critically ill patients.