Significats de human cf en anglès

Measurements and main results: IDO was defective in murine and human CF.

Additionally, we observed upregulation of ENaC protein levels in human CF bronchi.

PPMOs had low toxicity in human CF cells at doses that were antibacterial.

A human CF atrial cell line (cc) was used as control.

Conclusions: Loss of CFTR alters porcine airway smooth muscle function and may contribute to the airflow obstruction phenotype observed in human CF.

Acute and chronic respiratory infection models, which have been used in CF transgenic mice and mimic human CF lung pathology, are also taken into consideration.

Methods: Primary human CF (F508del homozygous) and non-CF airway epithelial cells were grown to terminal differentiation at the air-liquid interface on permeable supports.