Significats de human islet en anglès

The apelin-APJ signaling system is expressed in rodent and human islet cells.

We have now mapped and examined the function of human islet cis-regulatory networks.

Recent reports have cataloged human islet transcriptome but not compared single β-cells in detail.

The selection of enzyme blend is critical for the success of human islet isolations.

Pooled human islet cell complementary DNA served as the control.

Evaluation of viable β-cell mass contained in human islet preparations will be useful for selecting enzyme blends.

Conclusions: The fraction of large islets is a sensitive predictor of human islet transplantation outcomes in diabetic mice.

Here, we scrutinized ex vivo human islet cells from healthy donors and show that they exhibit de-differentiation signatures.

The purpose of this study was to determine whether this approach has utility for prediction of human islet allograft loss.

The procedure is now being used for the initiation of the second phase of clinical trials on human islet transplants.

These and similar analyses will provide better understanding of human islet biology and enhance the development of novel diabetes therapies.

We collected data from 61 human islet isolations and 188 subsequent in vivo mouse transplantations.

To minimize this potential hazard, we adapted our human islet processing procedure to use a GMP-manufactured, bovine neural tissue-free collagenase blend.

Taken together, our results demonstrated that JP-3-110 can be a safer immunosuppressive agent for human islet transplantation.

In 2007, the islet community was notified that the collagenase product most commonly used for human islet isolations contained bovine neural tissue contaminants.

Results: The RT-PCR carried out on total RNA from four distinct human islet preparations demonstrated the presence of peroxisome proliferator-activated receptor gamma mRNA.