Significats de human renin en anglès

These data strongly suggest that the human renin transgene exhibits both tissue- and cell-specific expression in transgenic mice.

Two assays were developed to differentiate human renin transcripts from endogenous mouse renin transcripts at the whole-tissue level.

In situ hybridization revealed the human renin mRNA to be localized and exquisitely restricted to renal juxtaglomerular cells.

Active human renin and human prorenin were found in the systemic circulation at levels consistent with previous transgenic models.

Kinetic analysis of compound 10 showed it to be a competitive inhibitor of human renin catalyzed proteolysis of human ANG.

The design of compounds based on pepstatin and on angiotensinogen sequence has led to very potent and specific human renin inhibitors.

Whereas human renin mRNA was permissively expressed in most tissues, the transgene was expressed mainly in JG cells in the kidney.

Transgenic mice containing the human renin gene were constructed with the aim of examining the tissue- and cell-specific expression of human renin.

Plasma renin activity assays using synthetic human renin substrate clearly demonstrated the elaboration of active human renin into the systemic circulation of transgenic mice.

High level human renin expression was evident in the kidney, adrenal gland, ovary, testis, lung, and adipose tissue of all four transgenic lines examined.

Human renin mRNA could also be detected at lower levels in the submandibular gland and heart of two different individual lines.