Meanings of human tau in anglès

We have characterized a novel monoclonal antibody, Tau-66, raised against recombinant human tau.

In this study, the full-length and several truncated human tau proteins were expressed from E. coli and purified.

Transgenic mice overexpressing the P301L mutant human tau protein exhibit an accumulation of hyperphosphorylated tau and develop neurofibrillary tangles.

Here we present mice that develop pathology from non-mutant human tau, in the absence of other exogenous factors, including beta-amyloid.

Mutations in the human tau gene leading to aberrant splicing have been identified in FTDP-17, an autosomal dominant hereditary neurodegenerative disorder.

Here, we address this question using a mouse model expressing the entire human tau gene with an FTD-associated mutation (V337M).

At 6 months of age, we observed widespread human tau expression with concomitant accumulation of hyperphosphorylated and abnormally folded proteinase K resistant tau.

Conclusions: This new mouse model can be used as a discovery tool in optimizing gene targeting therapeutics directed to reduce human tau mRNA levels.

Mutant, but not wild-type, human tau transgenic mice had aging-dependent repetitive and disinhibited behaviors, with synaptic deficits selectively in the ventral striatum and insula.

Here, using a combination of biophysical and computational approaches, we investigated the fibrillation dynamics of the human tau isoform 2N4R.