Significats de human telomerase en anglès

Several CRADs controlled by the human telomerase reverse transcriptase promoter have been developed.

These results establish that the human telomerase RT possesses unique polymerization determinants that distinguish it from other RTs.

To circumvent this obstacle, we immortalized primary human fetal SCs using the SV40 large T-antigen and human telomerase reverse transcriptase expression vectors.

Experimental design: The antitumor specificity of human telomerase reverse transcriptase and hypoxia response promoters was evaluated in a panel of tumor and normal cells.

Objective: We analyzed the functions and mechanisms of immune functions of human telomerase reverse transcriptase regulating dendritic cells (DC) treating sepsis of mice models.

Results: Human telomerase reverse transcriptase and hypoxia response promoters were activated in a tumor-selective manner or under hypoxia treatment in a broad panel of cells.