Significats de huntingtin en anglès

A possible cross-talk between mutant huntingtin and a-synuclein aggregates has been postulated.

N-terminal cleavage may be linked to mutant huntingtin's role in cell death.

These alterations may increase the susceptibility of striatal neurons to mutant huntingtin-mediated toxicity.

However, the huntingtin gene is ubiquitously expressed throughout the body.

The study involved genetically engineered mice with a version of the human huntingtin gene.

Its basis appears to be in huntingtin's aberrant protein-protein interactions with a variety of transcription factors.

We used polyclonal and monoclonal anti-fusion protein antibodies to identify native huntingtin in rat, monkey, and human.

This can be explained as nocodazole inhibits autophagosome-lysosome fusion, a key step in mutant huntingtin exon 1 clearance.

Only mutant huntingtin formed nuclear and cytoplasmic inclusions, which increased with polyglutamine expansion and with time after transfection.

Sequestration of mTOR impairs its kinase activity and induces autophagy, a key clearance pathway for mutant huntingtin fragments.

The mutated huntingtin is ubiquitous in somatic tissues, yet the pathologic changes are apparently restricted to the brain.

However, the important role of wild-type huntingtin in both HD and other neurological diseases has not been fully recognized.

Addressing the problem at its genetic root by suppressing mutant huntingtin expression is a promising therapeutic strategy for HD.

Identifying the subcellular localization of huntingtin and understanding its effects on global gene expression are critical to this endeavor.

In the cells expressing the mutant truncated huntingtin construct, numerous SDS-resistant aggregates were present in the cytoplasm and nucleus.

The protein-protein interactions of mutant huntingtin with transcriptional factors do not constitute conventional and easy targets for drug molecules.