Significats de hypomorphic allele en anglès

The hypomorphic allele produced can be repaired in situ by Cre-recombinase-mediated DNA excision.

A subset of mice expressing the hypomorphic allele is infertile.

Therefore, we have generated a hypomorphic allele of Rad51c in addition to a null allele.

This suggests an adaptive significance for this hypomorphic allele.

We demonstrate that each HS-affected family has at least one hypomorphic allele that results in extremely mild peroxisomal dysfunction.

Mice homozygous for the hypomorphic allele are viable and born at a frequency that is not significantly different from the expected Mendelian ratio.

A hypomorphic allele of Zic2 has demonstrated that in the mouse Zic2 is required for the timing of neurulation.

Therapeutic strategies aimed at inducing overexpression of hypomorphic alleles might be beneficial.

The combination of hypomorphic alleles of SkpA and hiw leads to enhanced synaptic growth.

Patients with underlying hypomorphic alleles in PRF1 may be predisposed to develop this toxicity.

In this view, therapies to enhance PERK signaling would benefit at-risk carriers of hypomorphic alleles.

Hypomorphic alleles show additive effects with respect to leg length and viability; and several heteroallelic lines were established.

Several dAP-2 alleles with DNA binding domain missense mutations are null in hemizygotes but have dominant negative effects when paired with hypomorphic alleles.

Seven hypomorphic alleles constitute a phenotypic series yielding hemizygous adults with legs ranging from 40-95% of normal length.