Significats de idiopathic pah en anglès

Conclusions: The prevalence of unexplained iron deficiency is significantly higher in idiopathic PAH than in CTEPH.

Methods and results: We documented increased HMGA1 in PAECs cultured from idiopathic PAH versus donor control lungs.

We hypothesized that serum CXCL10 is elevated in idiopathic PAH and that it is associated with clinical outcomes.

The serum study showed that patients with idiopathic PAH had lower serum iron and transferrin saturations than those with CTEPH.

The prevalence study was based on 85 patients with idiopathic PAH and 120 with CTEPH.

Both patients experienced exertional breathlessness during the third month after their uncomplicated delivery, and idiopathic PAH was diagnosed after an integrated assessment.

We also hypothesized that a subset of genes would discriminate between patients with idiopathic PAH and pulmonary hypertension related to secondary causes.

We have previously reported tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) immunoreactivity within pulmonary vascular lesions from patients with idiopathic PAH and animal models.

A separate group of 20 patients with idiopathic PAH and 24 with CTEPH with matching haemodynamics were prospectively investigated for serum factors affecting iron metabolism.

In comparison with the incidence of idiopathic PAH in the general population (1-2 per million), HIV-infected patients have a 2500-fold increased risk of developing PAH.