Progressive, degenerative disorder of the nervous system characterized by tremors, rigidity, bradykinesia, postural instability, and gait abnormalities; caused by a loss of neurons and a decrease of dopamine in the basal ganglia.
It has been hypothesized that idiopathicparkinsonism might be due to age-related attrition of dopamine neurons occurring long after an initial acute episode.
2
Helicobacter infection has been described as one switch in the pathogenic-circuitry of idiopathicparkinsonism (IP): eradication modifies disease progression and marked deterioration accompanies eradication-failure.