Significats de immortalize primary en anglès

We show that retroviral-mediated expression of E2A-HLF alone is sufficient to immortalize primary lymphoid progenitors.

Finally, we show that Tbx3 can immortalize primary embryo fibroblasts and that the RD1 repression domain is required for this activity.

To circumvent this obstacle, we immortalized primary human fetal SCs using the SV40 large T-antigen and human telomerase reverse transcriptase expression vectors.

Using the human immortalized primary cells, HBx was found to retain the ability to overcome active oncogene RAS-induced senescence that requires full-length HBx.