Significats de induce emt en anglès

Twist served as a linkage between the two pathways during TGF-β- induced EMT.

Aim: To investigate the role of miR-301a in hypoxia- induced EMT in PC cells.

TGF-β is long known to require Ras activation to induce EMT.

We investigated the miRNA-dependent mechanisms involved in nickel- induced EMT in lung epithelial cells.

While, MCM7 overexpression inhibited acid- induced EMT and supported tumor cell proliferation under acidic condition.

Hypoxia was able to induce EMT and enhance ability of invasion and migration in HCC cells.

Many tumor microenvironmental factors such as cytokines, growth factors, as well as chemotherapeutic agents may induce EMT.

RNA interference-mediated knockdown of Snail expression suppressed RhoGDI2- induced EMT and invasion, confirming that the effect was Snail-specific.

These findings suggest that p70S6K promotes IL-6- induced EMT and metastasis of HNSCC.

Conclusion: Snail- induced EMT represents a clinically relevant mechanism of UTUC progression and an attractive target for the treatment of patients with UTUC.

We showed that hypoxia- induced EMT could be enhanced by addition of recombinant Wnt3a while it was repressed by β-catenin small interfering RNA.

Conclusion: The newly identified HIF-2a-miR301a-TP63 signaling pathway may play a crucial role in hypoxia- induced EMT in PDAC cells.

Our results establish that KLF10 functions to suppress TGFβ- induced EMT, establishing a molecular basis for the dichotomy of TGFβ function during tumor progression.

In the current study, we characterize cell migration, contraction, and collagen production by esophageal epithelial cells that have undergone cytokine- induced EMT in vitro.

Knockdown of OLA1 in a lung adenocarcinoma cell line rendered the cells more resistant to TGF-β- induced EMT and the accompanied repression of E-cadherin.

Here, we sought to identify the subset of genes regulated in lung cancer by ZEB1, an E-box transcriptional repressor known to induce EMT.