Significats de induce nash en anglès

Finally, TSK inactivation protects mice from diet- induced NASH and liver transcriptome remodeling.

Brain-derived neurotrophic factor treatment reduced membrane TRKB-T1 protein and protected mice from diet- induced NASH.

Methods: We performed RNA sequencing and quantitative proteomic analyses on the livers from healthy and diet- induced NASH mice.

Hence, we investigated the chronology of whole body, tissue, and cellular events that occur during the evolution of diet- induced NASH.

Hepatocyte-specific inactivation of hnRNPU disrupted liver chromatin accessibility, activated molecular signature of NASH, and sensitized mice to diet- induced NASH pathogenesis.

In conclusion, we demonstrated that both LRP and LQP alleviated the severity of NASH in a high-fat diet- induced NASH mouse model.

Results: RNA sequencing and quantitative proteomic analyses revealed that diet- induced NASH triggers concordant reprogramming of the liver transcriptome and proteome in mice.

Conclusions: Global transcriptomic and proteomic profiling of healthy and NASH livers revealed the molecular signatures of diet- induced NASH and dysregulation of the liver secretome.

Systemic and hepatic inflammation was assessed either after 2 weeks on standard chow or after 8 weeks on high cholesterol diet (HCD) to induce NASH.