We tested this hypothesis in rats with carrageenin- induced pleurisy.

GILZ expression was increased during the resolution phase of LPS- induced pleurisy, especially in macrophages with resolving phenotypes.

Conclusions: The study may provide scientific basis to further understanding of the mechanism of STVO in anti-inflammatory effect of carrageenin- induced pleurisy.

The aim of the present study was to evaluate the anti-inflammatory activity of DEC in a mouse model of acute inflammation (carrageenan- induced pleurisy).