Significats de insoluble tau en anglès

This was accompanied by a decrease in brain iron levels and sarkosyl- insoluble tau.

The cellular insoluble tau exhibits classic features of neurofibrillary tangles.

The insoluble tau proteins were comprised mostly of four-repeat (4-R) isoforms.

Sarkosyl- insoluble tau showed paired helical and straight filaments, as well as more irregular rope-like filaments.

Significantly, analysis of secondary progressive multiple sclerosis brain tissue also revealed abnormally phosphorylated tau and the formation of insoluble tau.

Here, we show that P. aeruginosa infection elicits accumulation of detergent insoluble tau protein in the mouse brain and inhibits synaptic plasticity.

In both cases, immunoblotting of insoluble tau exhibited the pattern of selective accumulation of four-repeat tau, a finding that is also compatible with CBD.

The insoluble tau can be detected and quantified by thioflavin-S staining, thus allowing us to adapt our cellular model to a high-content image-based screening platform.

Using genetic and pharmacological methods, we demonstrate that inhibition of autophagy increases whereas enhancement of autophagy reduces insoluble tau in our seeding based cellular model.

Administration of a second GSK-3 inhibitor also correlated with reduced insoluble tau levels, supporting the idea that lithium exerts its effect through GSK-3 inhibition.