Significats de l-serine en anglès

In patient 2 treatment with l-serine led to an improvement of spasticity.

A treatment with oral l-serine was started at age 4.5 years and 3 months respectively.

A previous study revealed a novel and unexpected interaction between the hydroxyl group of the l-serine substrate and the 5'-phosphate group of PLP.

L-serine or L-cysteine incubation increased NO and S1P levels in mouse aorta.

Here, we have investigated if L-serine contributes to the vasorelaxant effect.

Key results: L-serine relaxed aorta rings in an endothelium-dependent manner.

The enzyme also catalyzes the dehydration of D- and L-serine.

We conclude that 3-PGDH can be treated effectively by a combination of L-serine and glycine.

Serine racemase (SR) is the enzyme that converts L-serine to D-serine.

The L-serine effect involves both NO and S1P.

L-serine supplementation also improved measures of motor and sensory performance as well as measures of male fertility.

The mutant forms of the enzyme show a shift from their canonical substrate L-serine to the alternative substrate L-alanine.

Computer graphics models of the wild-type enzyme complexed with L-serine and D-serine provided an insight into the catalytic mechanisms of both reactions.

L-serine supplementation is a possible candidate therapy but the lack of responsive outcome measures is a barrier for undertaking clinical trials in HSN1.

One mutant exhibits greatly reduced chemotaxis toward L-serine but has no detectable defect either in uptake or in oxidative metabolism of that compound.

Second, various serine analogues were also examined; the data indicated that the alpha-carboxyl group of L-serine was quite important for substrate recognition by SPT.