She had leptomeningealcarcinomatosis, in which cancer cells invade the fluid-filled membrane surrounding the brain.
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Central nervous system disease was defined as one or more brain metastases or as leptomeningealcarcinomatosis.
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Adequate early diagnosis and treatment of CVST enabled an excellent survival rate for the patient, despite leptomeningealcarcinomatosis.
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Patients and methods: We report a case of leptomeningealcarcinomatosis secondary to endometrial carcinoma and 2 complex cervix cancer cases.
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Effective treatment with gefitinib was administered, and the patient survived for 10 months after the diagnosis of CVST and leptomeningealcarcinomatosis.
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Harper had revealed to People magazine in March 2013 she had leptomeningealcarcinomatosis - cancer cells in the membrane of her brain.
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It is also considered to be part of the spectrum of leptomeningealcarcinomatosis and is associated with a high incidence of brain metastases.
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Results and discussion: Leptomeningealcarcinomatosis is usually diagnosed late in the course of the disease, and most reports concern ovarian cancer patients.