Significats de lipin en anglès

We infer that sterol-mediated regulation of lipin 1 gene transcription modulates triglyceride accumulation.

However, the molecular function of lipin 1 is unclear.

These observations place lipin 1 as a potentially important link between triacylglycerol synthesis and adipose tissue inflammation.

The lipin 1-mediated suppression of VLDL-TAG secretion was linked to the peptide motif mediating its transcriptional-regulatory effects.

The results suggest that insulin and epinephrine control lipin primarily by changing localization rather than intrinsic PAP activity.

Thus, lipin appears to have critical roles in both adipocyte differentiation and in the function of mature adipocytes.

Previous studies revealed that lipin plays a critical role in adipogenesis, explaining the adipose-deficient phenotype of the fld mouse.

However, the expression of candidate genes required for VLDL assembly and secretion was unaltered by lipin 1 activation or deficiency.

Our results indicate that lipin is required for normal adipose tissue development, and provide a candidate gene for human lipodystrophy.

The PAP-specific activity of lipin was not affected by the hormones or by dephosphorylation of lipin with protein phosphatase 1.

We sought to evaluate the effects of lipin 1 on hepatic TAG synthesis and secretion by gain-of-function and loss-of-function approaches.

SP1 regulated lipin gene expression that may participate in SP1-induced fat deposition and starvation resistance.

Conclusions: Collectively, these studies reveal new and unexpected effects of lipin 1 on hepatic TAG metabolism and obesity-related hepatic insulin resistance.

These results indicate that lipin is a major PAP in vivo and that the loss of PAP activity contributes to the fld phenotype.

However, the ratio of soluble to microsomal lipin was markedly increased in response to insulin and decreased in response to epinephrine and oleic acid.

Lipin 1 overexpression did not alter TAG synthesis rates but significantly suppressed VLDL-TAG secretion.