Significats de malignant clone en anglès

Multiple myeloma is a plasma cell malignant clone proliferation diseases and has been remained incurable.

Currently, only allogeneic stem cell transplantation appears to be effective in eradicating or suppressing the malignant clone.

In BC, the malignant clone developed a new additional cytogenetic abnormality consisting of a deletion of chromosome 21.

In young patients, the goal of treatment is eradication of the preleukemic malignant clone and reconstitution of normal hematopoiesis.

However, remissions are short-lived because the treatment fails to induce complete differentiation and fails to eradicate the malignant clone.

PBPC collection could be optimized either by reducing contamination by the malignant clone or by increasing hematopoietic quality of the graft.

Analysis of individual cases indicated that the level of IL-6 gene expression was strongly correlated with the presence of immunoblasts within the malignant clone.

Preclinical investigations indicate that reciprocal interaction between the malignant clone and the microenvironment serve to create a hostile milieu that reinforces ineffective blood cell production.