Significats de matched sibling en anglès

None of the six patients receiving DLI from a matched sibling responded.

Allocation to treatment was performed according to availability of a matched sibling donor.

Six patients had been transplanted from an HLA- matched sibling and 15 from other donors.

In these diseases, matched sibling donor bone marrow transplantation is the standard for comparison.

Fifteen patients were included in the study; 14 had a fully HLA matched sibling donor.

Mobilization of PBPC was investigated in 19 healthy matched sibling donors using two different rhG-CSF regimens.

Studies are in progress for using this type of protocol in situations without a HLA matched sibling donor.

Forty-eight percent received a myeloablative conditioning regimen and 78% received stem cells from matched sibling donors.

In older patients and in those without a matched sibling donor, immunosuppressive therapy is the usual first option.

PB was considered the most appropriate source of hematopoietic stem cells for HLA- matched sibling and unrelated donor transplants.

The source of bone marrow was an unrelated donor in six, matched sibling in four, and mismatched related in one.

A third patient undergoing a CD34+ selected HLA- matched sibling mini-allograft for relapsed MM showed graft failure shortly after RSV infection.

These results comparing two different approaches support the use of a haploidentical family donor for high-risk AML patients lacking a matched sibling donor.

In summary, the use of UCB is an excellent donor choice for pediatric patients with AML when a matched sibling cannot be identified.

Therefore, we aimed to provide an evidence-based review and recommendations for selecting donors for adults without an HLA- matched sibling or an HLA-matched adult unrelated donor.

Here we report a prospective comparison of immune reconstitution in recipients of UD-HSCT and of unmanipulated bone marrow from matched sibling donors (MSD-BMT).