Significats de mediate autoimmunity en anglès

Complement deficiency or blockade attenuates T-cell- mediated autoimmunity and delays allograft rejection in mice.

Our findings establish DCAF2 as a novel target for T cell- mediated autoimmunity or inflammatory diseases.

Here we show a critical role of pDCs in TLR7- mediated autoimmunity using gene-modified mice with impaired expression of Siglec-H and selective ablation of pDCs.

Expression of two different TCR alpha chains by one T cell (dual TCR) is discussed as a potential mechanism underlying T-cell mediated autoimmunity.

Thus, our study has revealed a hitherto unknown immune function of U11snRNA, providing insight into TLR7- mediated autoimmunity and its potential for further therapeutic applications.