Significats de mediate vasoconstriction en anglès

Animal studies also demonstrated that postsynaptic alpha 2-adrenoceptors mediate vasoconstriction in coronary and femoral vascular beds.

There is evidence for aggravation of the chronic cardiac pathology by endothelin- mediated vasoconstriction.

Moreover, we illustrate greater a 1 -adrenergic- mediated vasoconstriction may contribute to our initial observations.

Alpha-adrenergic- mediated vasoconstriction may offset vasodilation during PDE-5 inhibition and may explain the significant hypotension observed in patients taking alpha-blockers with sildenafil.

This study also suggests that the absence of endothelium modifies the alpha 1-adrenoceptor- mediated vasoconstriction probably by altering the transduction signalling mechanisms.

The mechanisms of this non-renin mediated vasoconstriction are less apparent, but may include calcium mediated vasoconstriction, and the effects of increased cytosolic content.

This may be related, at least in part, to the alleged amplifying effect of 5-HT on alpha 1-adrenoceptor- mediated vasoconstriction.

Conclusions: S-0139 dose-dependently blocks ET-1- mediated vasoconstriction in the forearm and has a prolonged duration of effect beyond that expected from its pharmacokinetic profile.