Significats de metastatic cascade en anglès

To date, the significance of angiogenesis in the peritoneal metastatic cascade is unknown.

These findings suggest that targeting the RKIP pathway may diminish the metastatic cascade.

Thus, we propose that avβ3 integrin is one of the downstream factors regulated by BSP in the breast cancer-bone metastatic cascade.

IL-6 has also been shown to act as a trigger of the EMT, the hypothesized first step in the metastatic cascade.

A group of genes, termed metastasis suppressor genes (MSG), encode for proteins that inhibit various steps of the metastatic cascade.

This review will describe the involvement of specific cell adhesion receptors, extracellular matrix molecules, and cell dissociating cytokines in the metastatic cascade.

Furthermore, EHX was found to disrupt the metastatic cascade of breast cancer cells by the inhibition of cell proliferation, migration, invasion, and colonization.

The steps in the metastatic cascade and the vicious cycle within bone offer unique targets for adjuvant treatments to treat and cure bone metastases.

Our review highlights the contrast between the abundance of insight gained into the events that constitute the metastatic cascade and the paucity of therapeutic options.

In circulation, cancer cells induce platelet activation, leading to the formation of a cancer cell-encircling platelet cloak which facilitates each step of the metastatic cascade.