Significats de metastatic dissemination en anglès

TGF-beta signaling and EMT have been implicated in metastatic dissemination of carcinoma.

Loss of E-cadherin promotes tumor metastatic dissemination and predicts poor prognosis.

Conclusions: P-glycoprotein is probably involved in the processes of local invasion and metastatic dissemination.

These data support a potential therapeutic strategy for inhibiting distant metastatic dissemination via targeting tumor-associated lymphatic remodeling.

Here, they contribute to immunosuppression, enabling the establishment and persistence of solid tumors as well as metastatic dissemination.

The metastatic dissemination of cancer cells is often acquired through a process of epithelial-mesenchymal transition (EMT).

Malignant insulinoma is a rare form of cancer with a poor prognosis because of metastatic dissemination and untreatable hypoglycemia.

Accumulating evidence suggests that platelets play a key role in cancer metastatic dissemination through their multilevel interaction with tumor cells.

Both patients had undergone surgical intervention for a thyroid nodule more than 15 years before the diagnosis of thyrotoxicosis and metastatic dissemination.

Karyotypic and phenotypic analysis of human disseminated cancer cells and primary tumours corroborated the relevance of these findings for human metastatic dissemination.

Accumulating data suggest that metastatic dissemination often occurs early during tumour formation, but the mechanisms of early metastatic spread have not yet been addressed.

Because local invasion is thought to be a necessary first step in metastatic dissemination, EMT and epithelial plasticity are hypothesized to contribute to tumor progression.

In particular, the tumor microenvironment can instruct carcinoma cells to undergo a morphogenesis program termed epithelial-to-mesenchymal transition (EMT) to facilitate local invasion and metastatic dissemination.

Metastatic dissemination of the disease resulted in the death of the patient in Case 3.

Introduction: Metastatic dissemination is an important factor for the prognosis of patients with gastro-intestinal cancer.

Metastatic dissemination of cancer cells to distal organs is the major cause of death for patients suffering from the aggressive basal-like breast cancer (BLBC) subtype.