Significats de mutational hotspots en anglès

It is plausible that their atypical presentation may be due to the location of the ALMS1 mutations outside the usual mutational hotspots.

We have studied DNA binding and transactivation (TA) properties of human wild-type and mutant p53 proteins representing four major mutational hotspots.

Overall, these results indicate that both recombinational and mutational hotspots have played significant roles in shaping the haplotype variation at the LPL locus.

These remarkable structures can have profound effects on chromosomes and organisms, ranging from mutational hotspots in bacteria to causes of intellectual disability in humans.

Mutational hotspots in the cornea-specific keratin genes K3 and K12 were scanned for mutations by single-strand conformation analysis.