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Serial nasallavage and induced sputum samples were assessed for viral copy number and inflammatory cell counts.
2
Biomarkers in nasallavage (NL) fluid may be useful in determining the presence and severity of upper airway inflammation.
3
The nasallavage fluid revealed no increase in eosinophils or IL-5, and the nasal airway resistance did not increase after challenge either.
4
Results: Histamine produced significant increases in nasallavage fluid levels of alpha2-macroglobulin at all observation points (5 through 55 minutes after treatment).
5
Nasallavage mediators were analysed using a sensitive multiplexed bead immunoassay system.
6
The levels of histamine and TAME-esterase activity in recovered nasallavages were not changed significantly by either pre-treatment at either dose.
7
The nasal responses were monitored by means of symptom scores and measurements of N alpha-p-tosyl-L-arginine methyl esterase (TAME) activity in nasallavages.