Significats de neonatal lethality en anglès

Strikingly, gene-targeting knockout of PHF14 in mice resulted in a neonatal lethality due to respiratory failure.

We have generated a mouse model of LPL deficiency which was rescued from neonatal lethality by somatic gene transfer.

Inactivation of c-cbl completely reversed the neonatal lethality seen in SLP-76-deficient mice and partially reversed the T cell development arrest in these mice.

We have discovered an unanticipated role for MEF2C in the neural crest, where tissue-specific inactivation results in neonatal lethality due to severe craniofacial defects.

SLP-76-deficient mice show a high frequency of neonatal lethality; and in surviving mice, T cell development is blocked at the DN3 stage.